He was an acting student at the Accademia Nazionale di Arte Drammatica Silvio D’Amico.
Tommasco Scalia in Gianni Amelio’s Open Doors was the role which made him well known, a role that gave him a Nastro d’Argento, a Ciak d’oro and a special European Film Award as European Discovery of the Year.
During 2010, for his performance in Ferzan Özpetek’s Loose Cannons, Ennio Fantastichini won a David di Donatello for best supporting actor and a second Nastro d’Argento in the same category.
He died due to leukemia in Naples.
Ennio Fantastichini the actor passed away at 63 years old.