In 1959, he played for Real Madrid from Segunda División club CA Osasuna.
On September 11, 1960, Pachín made his La Liga debut in a 1–0 away loss against Atlético Madrid.
After his debute, he became the starter in that and the following four seasons.
Then, in May 1968, he left the Merengues, after his many appearances in 218 competitive games, in which he scored two goals.
Pachin was the winner of 11 major titles during his game time, this also including seven national championships.
Among his accomplishments is the 1960 and 1966 versions of the European Cup, adding to the last victories with a joined eight appearances and a sum of 32 during his profession
From 1968 to 1969, he returned to the second level for the campaign, where he played for Real Betis.
In 1971, Pachin resigned after a spell with novices Club Deportivo Toluca, at that point filled in as an administrator for a very long time, never in higher than the subsequent level.
One of his greatest accomplishment was to elevate Hércules CF to the first class in 1984, despite the fact that he just contributed with six matches to that accomplishment.
Enrique Pérez Díaz was the winner of eight caps for the Spain national team.
On May 15, 1960, he won his first game in a 3–0 friendly win over England, after that Pachin was selected for the squad that took part at the 1962 FIFA World Cup, competing against Mexico and Brazil in an eventual group stage exit.
Enrique Pérez Díaz passed away on Febuary 10, 2021.